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Use of REV-dependent HIV reporter cell, REV-CEM-GFP/Luc, helps lead to discovering small molecular inhibitors that block the HIV host dependency factor LIMK1
The actin cytoskeleton plays an important role in HIV entry, intracellular migration, and viron release. LIM domain kinase (LIMK) regulates actin cytoskeleton by phosphorylating cofilin. HIV can gain..
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